NAG Assay Kits and Controls
N-acetyl-β-D-glucosaminidase (NAG, hexosamindase) is measured in urine as a well-established, non-invasive marker of AKI, nephrotoxicity and the progression of renal disease. Renal disease is progressive resulting in deterioration of renal function. This will eventually lead to renal failure which necessitates either renal dialysis or transplantation.
Hexosaminidase (HEX) isoenzymes are present in different organs and tissues. The acidic A and basic B forms are present in the liver, kidney and spleen. HEX is also assayed in laboratories monitoring genetic disease in suspected cases of Tay-Sach disease and Sandhoff’s disease. The A-form of HEX is absent from Tay-Sach disease which is most commonly found in Ashkenazi Jews. This kit can be used in conjunction with heat treatment or ion-exchange chromatography in the quantitation of the A and B-forms of hexosaminidase.
Assay kits are available in various sizes to suit either large scale analysers or individual laboratory investigations.